Figure 6.
Flow cytometric assessment of CD119 expression on monocytes. Overlay of patients with CR and PD forms of IFN-γR1 deficiencies. (A) Gating of monocytes on side scatter vs. CD14 PCP5.5. (B) CR deficiency showing absent expression of CD119 where green is patient unstained, red patient stained, and blue control stained. (C) CR deficiency showing reduced expression compared with a healthy control. (D) PD deficiency showing increased expression. (E) Percent expression, controls vs. CR IFN-γR1 deficiencies (asterisks indicate statistical significance: ****P < 0.0001), CR IFN-γR1 deficiencies vs. PD IFN-γR1 deficiencies (asterisks indicate statistical significance: ***P < 0.0001). (F) SI of controls vs. PD IFN-γR1 deficiency (asterisks indicate statistical significance: *P < 0.0172), CR IFN-γR1 deficiencies vs. PD IFN-γR1 deficiencies (asterisks indicate statistical significance: ***P < 0.0003).

Flow cytometric assessment of CD119 expression on monocytes. Overlay of patients with CR and PD forms of IFN-γR1 deficiencies. (A) Gating of monocytes on side scatter vs. CD14 PCP5.5. (B) CR deficiency showing absent expression of CD119 where green is patient unstained, red patient stained, and blue control stained. (C) CR deficiency showing reduced expression compared with a healthy control. (D) PD deficiency showing increased expression. (E) Percent expression, controls vs. CR IFN-γR1 deficiencies (asterisks indicate statistical significance: ****P < 0.0001), CR IFN-γR1 deficiencies vs. PD IFN-γR1 deficiencies (asterisks indicate statistical significance: ***P < 0.0001). (F) SI of controls vs. PD IFN-γR1 deficiency (asterisks indicate statistical significance: *P < 0.0172), CR IFN-γR1 deficiencies vs. PD IFN-γR1 deficiencies (asterisks indicate statistical significance: ***P < 0.0003).

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