Figure 5.
Defective IFN-γ production following IL-12 stimulation and altered baseline IFN-γ levels in IL-12Rβ1–deficient patients. (A) Impaired cellular response to IL-12p70. Production of IFN-γ by whole blood from IL-12Rβ1–deficient patients and controls, either unstimulated or stimulated with BCG alone or with BCG and recombinant IL-12p70. (B) Baseline serum IFN-γ levels in patients with IL-12Rβ1 deficiency and controls (asterisks indicate statistical significance: ***P < 0.0001).

Defective IFN-γ production following IL-12 stimulation and altered baseline IFN-γ levels in IL-12Rβ1–deficient patients. (A) Impaired cellular response to IL-12p70. Production of IFN-γ by whole blood from IL-12Rβ1–deficient patients and controls, either unstimulated or stimulated with BCG alone or with BCG and recombinant IL-12p70. (B) Baseline serum IFN-γ levels in patients with IL-12Rβ1 deficiency and controls (asterisks indicate statistical significance: ***P < 0.0001).

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