Figure 4.
Flow cytometric expression of pSTAT4 on activated T cells. (A) Gating of activated T cells on side scatter versus CD3 FITC. (B–D) Complete IL-12Rβ1 deficiency showing (B) absent, (C) reduced expression, and (D) reduced MFI in patients after stimulation with IL-12p70 compared with healthy controls, where green is patient unstained, red patient stained, and blue control stained. (E) Normal pSTAT4 expression in both IL-12Rβ1–deficient patients and controls after stimulation with IFN-α. (F) Percent expression of pSTAT4 in IL-12Rβ1 deficiency patients vs. controls after stimulation with IL-12p70 (asterisks indicate statistical significance: ****P < 0.0001) and IFN-α (ns: not significant).

Flow cytometric expression of pSTAT4 on activated T cells. (A) Gating of activated T cells on side scatter versus CD3 FITC. (B–D) Complete IL-12Rβ1 deficiency showing (B) absent, (C) reduced expression, and (D) reduced MFI in patients after stimulation with IL-12p70 compared with healthy controls, where green is patient unstained, red patient stained, and blue control stained. (E) Normal pSTAT4 expression in both IL-12Rβ1–deficient patients and controls after stimulation with IFN-α. (F) Percent expression of pSTAT4 in IL-12Rβ1 deficiency patients vs. controls after stimulation with IL-12p70 (asterisks indicate statistical significance: ****P < 0.0001) and IFN-α (ns: not significant).

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