Complete T cell antigen promotes the infiltration of self-replicable CD8 + T cells and suppresses their exhaustion in the tumor. (A and B) The frequency of CD8+ T cell fractions indicated by antibodies in the DLNs of MC38 tumor-bearing mice treated with or without Bpmel-SIY-OVAII cell adjuvant, as investigated every 3 days (left, n = 3 per group per time point). Representative images and their frequencies on day 15 are also shown (right). (C–F) The frequency of CD8+ T cell fractions defined by the indicated cell surface markers in tumors with or without Bpmel-SIY-OVAII cell adjuvant treatment, as investigated every 3 days (left, n = 3 per group per time point). Representative images and frequencies at the indicated time points are shown (right). Student’s t test was used for statistical analysis. *P < 0.05. All data are representative of three similar experiments.