Schematic model summarizing the effect of ErbB3 in vesicular trafficking. ErbB3, in a ligand-independent manner, engages with Arf6–GGA3–Rabaptin5 endosomal sorting complex, to promote early recycling of TfR and Integrin β1. Depletion of ErbB3 or its effectors Rabaptin5 or GGA3 reroutes Integrin β1 from endocytic recycling toward lysosomal degradation and secretion as EV cargo. Created in BioRender.