Matriptase/PAR-2 signaling and promotion of metastatic OvCa dissemination. (A) Proposed model of a matriptase/PAR-2/PI3K/Akt/MMP9/E-cadherin signaling axis which promotes OvCa spheroid dissemination. (B) Kaplan–Meier progression-free survival analysis of a cohort of OvCa patients stratified by matriptase mRNA expression above the median (n = 281; logrank P = 0.0072) or matriptase mRNA expression below the median (n = 281; logrank P = 0.15; C) using publicly available data obtained from KMPlotter. All patients who expressed CA125 mRNA levels in lower quartile and outlier arrays were excluded.