Inclusion of partial occupancies in simulations of segregated assembly models does not mimic predictions of random mixing. (A) Digestion time course for segregated β2 and β3 a populations, each with partial occupancy of P = 0.8, for β3 a/β2 ratios of 1, 0.8, 0.667, 0.5, 0.333, 0.2, and 1.0. (B) As in A, but with P = 0.6. (C) Comparison of digestion time course for β3a/(β3a+β2) ratios of 1(green), 0.5 (black), and 0 with occupancies within each segregated population of 1.0, 0.8, and 0.6. (D) Plot of the AST vs. fss relationships for β3a/(β2+β3a) ratios of 1.0 (green), 0.8, 0.667, 0.5 (black), 0.333, 0.2, and 0 (red) for the case of partial occupancies of 0.8. (E) As in D, but with partial occupancies of 0.6. Partial occupancies do not alter the absolutely linear dependence of slow tail reduction on fractional removal of β3a N termini.
Figure S3.

Inclusion of partial occupancies in simulations of segregated assembly models does not mimic predictions of random mixing. (A) Digestion time course for segregated β2 and β3 a populations, each with partial occupancy of P = 0.8, for β3 a/β2 ratios of 1, 0.8, 0.667, 0.5, 0.333, 0.2, and 1.0. (B) As in A, but with P = 0.6. (C) Comparison of digestion time course for β3a/(β3a+β2) ratios of 1(green), 0.5 (black), and 0 with occupancies within each segregated population of 1.0, 0.8, and 0.6. (D) Plot of the AST vs. fss relationships for β3a/(β2+β3a) ratios of 1.0 (green), 0.8, 0.667, 0.5 (black), 0.333, 0.2, and 0 (red) for the case of partial occupancies of 0.8. (E) As in D, but with partial occupancies of 0.6. Partial occupancies do not alter the absolutely linear dependence of slow tail reduction on fractional removal of β3a N termini.

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