RF-based catabolites impact on in vitro MR1-dependent T cell activation. (A–O) Bar graphs show three independent biological replicates for the CD69 expression measured on the surface of SKW-3 overexpressing the typical MAIT cell clone (A–F) MBV28 (TRAV1-2+ TRBV28+), (G–L) the atypical MAIT MAV36 (TRAV36+ TRBV28+), or (M–O) the MR1 autoreactive clone DGB129 (TRAV29+ TRBV12-4+) cocultured with C1R.MR1 cells in the absence (labeled “activation”) or presence of (labeled “inhibition”) 5-OP-RU after preincubation with titrated quantities of indicated ligands. Individual data points are technical replicates within the same experiment.
Figure S3.

RF-based catabolites impact on in vitro MR1-dependent T cell activation. (A–O) Bar graphs show three independent biological replicates for the CD69 expression measured on the surface of SKW-3 overexpressing the typical MAIT cell clone (A–F) MBV28 (TRAV1-2+ TRBV28+), (G–L) the atypical MAIT MAV36 (TRAV36+ TRBV28+), or (M–O) the MR1 autoreactive clone DGB129 (TRAV29+ TRBV12-4+) cocultured with C1R.MR1 cells in the absence (labeled “activation”) or presence of (labeled “inhibition”) 5-OP-RU after preincubation with titrated quantities of indicated ligands. Individual data points are technical replicates within the same experiment.

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