Dissecting the molecular functions of p120-catenin in vivo. (A) Optical slices of immunostained tissue sections show decreased E-cadherin in Ctnnd1f/f; CrectTg/0 mutants (n = 2) compared with controls (n = 2) at 10ts. Scale bar, 20 μm. (B)Cdh1f/f; CrectTg/0 embryo faces appear similar to controls at E12.5. Scale bar, 500 μm. (C) Schematic of p120-catenin protein illustrating the location of amino acid substitutions. CC, coiled-coil domain; ARM, armadillo domain. (D) Schematic of Ctnnd1 illustrating the location of corresponding point mutations. (E–H) Four Ctnnd1 point mutation alleles examined at E12.5 compared with controls. Only Ctnnd1K401M/f; CrectTg/0 mutants (G) (8/8) exhibit cleft lip (arrows). Scale bar, 500 μm.
Figure 5.

Dissecting the molecular functions of p120-catenin in vivo. (A) Optical slices of immunostained tissue sections show decreased E-cadherin in Ctnnd1f/f; CrectTg/0 mutants (n = 2) compared with controls (n = 2) at 10ts. Scale bar, 20 μm. (B)Cdh1f/f; CrectTg/0 embryo faces appear similar to controls at E12.5. Scale bar, 500 μm. (C) Schematic of p120-catenin protein illustrating the location of amino acid substitutions. CC, coiled-coil domain; ARM, armadillo domain. (D) Schematic of Ctnnd1 illustrating the location of corresponding point mutations. (E–H) Four Ctnnd1 point mutation alleles examined at E12.5 compared with controls. Only Ctnnd1K401M/f; CrectTg/0 mutants (G) (8/8) exhibit cleft lip (arrows). Scale bar, 500 μm.

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