Phenotyping of peripheral leukocytes from the two patients. (A–D) Mass cytometry performed in fresh whole blood of (A) mononuclear myeloid cells, (B) NK cells, (C) T cells, and (D) B cells. pDC, plasmacytoid dendritic cells, RTE, recent thymic emigrant, CM, central memory, EM, effector memory, TEMRA, T effector memory CD45RA⁺, TFH, T follicular helper, γδ, gamma-delta, Treg, T regulatory cells, iNKT, invariant natural killer T, MAIT, mucosal associated-invariant T cells, MZ, marginal-zone.