Clinical phenotypes associated with genes on the frequently deleted segments of chr. 22q11.2. (A) Fetal and postnatal clinical problems associated with 22q11.2DS arising from chromosomal deletions on 22q11.2. The red lines depict several of the low copy repeats (LCRs) in the chr. 22q11.2 region that result in the 3- and 1.5-Mb deletions. (B) Chromosomal map with several of the genes indicated along with their impact on the immune and neuronal systems. The blue and black defines the transcript direction. Note that PRODH and DGCR6 are encoded at the same location and transcribed in opposite directions. BioRender was used for components of the image. ILC, Innate lymphoid cells.