Figure 9.
Moesin deletion increases bone degradation and osteoclast activity in vivo. (A) Serum bone degradation marker analysis. CTX levels (ng/ml) in the serum of 11-wk-old male mice. Each circle represents a mouse, n = 8 WT and n = 7 Msn−/− mice, means ± SDs are shown. (B–D) Histological analysis. (B and C) Histograms indicate the mean ± SD of bone surface (B) and TRAP+ surface per bone surface (C) for each condition. Animal groups were composed of four mice of each genotype. N ≥ 2–3 sections chosen among the most median part of the bone. Each circle represents a single bone section and each mouse is represented by one color. (D) Images from histological analysis using TRAP staining (osteoclasts in purple) and fast green (bone is green) on femurs from WT mice and Msn−/− mice. Scale bars, 50 µm.

Moesin deletion increases bone degradation and osteoclast activity in vivo. (A) Serum bone degradation marker analysis. CTX levels (ng/ml) in the serum of 11-wk-old male mice. Each circle represents a mouse, n = 8 WT and n = 7 Msn−/− mice, means ± SDs are shown. (B–D) Histological analysis. (B and C) Histograms indicate the mean ± SD of bone surface (B) and TRAP+ surface per bone surface (C) for each condition. Animal groups were composed of four mice of each genotype. N ≥ 2–3 sections chosen among the most median part of the bone. Each circle represents a single bone section and each mouse is represented by one color. (D) Images from histological analysis using TRAP staining (osteoclasts in purple) and fast green (bone is green) on femurs from WT mice and Msn−/− mice. Scale bars, 50 µm.

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