Large deletion in the X-chromosome and the supply concept with non-cryopreserved Kx− RBCs. (A) Schematic representation of the large, previously unknown ∼6-Mb deletion identified by stepwise partitioning of the Xp21.1 region (3). Genes involved by this deletion and their orientation of transcription are displayed as blue arrows. (B) Managing the supply with Kx− RBCs; ZH: Zurich, Switzerland; FR: Freiburg, Germany. Cartoons were created with BioRender.