Gene variants reported in two or more publications. (A) Percentage of patients with disease-causing or -associated variants identified from all patients with CVID. Each dot represents an individual study (n, 19 studies); the line represents the calculated median. (B) Median percentages of patients with disease-causing or -associated gene variants determined from total patients who were genetically tested. (C) Median percentages of patients with disease-causing or -associated variants determined from total number of patients with gene variants identified.