The human genetic causes of AAN-I-IFN and their consequences. Molecules shaded in pink color are known human genetic defects underlying thymic T cell tolerance to self (I-IFN) that result in the generation of AAN-I-IFN. The AAN-I-IFN impair I-IFN–mediated antiviral immunity in the peripheral and specific organs, including the brain, thereby underlying severe arboviral diseases. This figure was created using the BioRender app (https://biorender.com).