Simulation of pharmacological blockade in the Trpm1 KO circuit model. (A ₁ –A ₅ ) Simulated blockade of glycinergic synaptic transmission. Each panel shows the membrane potential change in OFF RGC (A₁), synaptic conductance from OFF CBC to OFF RGC (A₂), synaptic conductance from AII AC to OFF RGC (A₃), membrane potential change in ON RGC (A₄), and synaptic conductance from ON CBC to ON RGC (A₅). Horizontal bars indicate light stimulation. (B₁–B₅) Simulated blockade of glutamatergic synaptic transmission. Panel arrangement is as in A. (C₁–C₅) Simulated blockade of gap junctions. Panel arrangement is as A and B.