Resting membrane potential of RBCs in WT and Trpm1 KO mouse retinas. (A) RBC membrane potential traces recorded from the WT (black) and Trpm1 KO (magenta) mouse retinas. (B) Resting membrane potential of RBCs in the WT and Trpm1 KO mouse retinas (WT: −53.5 ± 1.0 mV, n = 6 cells from five mice; Trpm1 KO: −71.4 ± 1.9 mV, n = 7 cells from six mice; P = 8.4 × 10−6). (C) Averaged I–V curves of RBCs in WT (triangle, black, n = 6 cells from five mice) and Trpm1 KO (square, magenta, n = 7 cells from six mice) mouse retinas. −80 mV: P = 0.0007; −70 mV: P = 0.0007; −60 mV: P = 0.001; −50 mV: P = 0.02. (D) Slope conductance of RBCs in the WT and Trpm1 KO mouse retinas (WT: 0.86 ± 0.13 nS, n = 6 cells from five mice; Trpm1 KO: 0.17 ± 0.05 nS, n = 7 cells from six mice; P = 0.0002). Data are presented as the mean ± SEM. An unpaired t test was used for statistical analysis. n.s., not significant; *P < 0.01; **P < 0.01; ***P < 0.001.
Figure 4.

Resting membrane potential of RBCs in WT and Trpm1 KO mouse retinas. (A) RBC membrane potential traces recorded from the WT (black) and Trpm1 KO (magenta) mouse retinas. (B) Resting membrane potential of RBCs in the WT and Trpm1 KO mouse retinas (WT: −53.5 ± 1.0 mV, n = 6 cells from five mice; Trpm1 KO: −71.4 ± 1.9 mV, n = 7 cells from six mice; P = 8.4 × 10−6). (C) Averaged I–V curves of RBCs in WT (triangle, black, n = 6 cells from five mice) and Trpm1 KO (square, magenta, n = 7 cells from six mice) mouse retinas. −80 mV: P = 0.0007; −70 mV: P = 0.0007; −60 mV: P = 0.001; −50 mV: P = 0.02. (D) Slope conductance of RBCs in the WT and Trpm1 KO mouse retinas (WT: 0.86 ± 0.13 nS, n = 6 cells from five mice; Trpm1 KO: 0.17 ± 0.05 nS, n = 7 cells from six mice; P = 0.0002). Data are presented as the mean ± SEM. An unpaired t test was used for statistical analysis. n.s., not significant; *P < 0.01; **P < 0.01; ***P < 0.001.

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