Oscillatory synaptic currents are eliminated by blockers, which affect the pathways involving AII AC. (A–C) Effects of synaptic blockers on IPSCs in OFF αRGCs. IPSCs recorded from OFF αRGCs in the control condition (left). Effects of blockers on IPSCs (center). PSDs in the control condition (black) and blocker conditions (magenta) (right). (D) Ratios of IPSC amplitudes in the presence of blockers to those under control conditions in OFF αRGCs (STR: 0.27 ± 0.08, n = 4 cells from three mice; P = 2.69 × 10−3, DNQX + d-AP5: 1.12 ± 0.25, n = 4 cells from four mice; P = 0.66, MFA: 0.19 ± 0.01, n = 3 cells from three mice; P = 1.71 × 10−4). (E–G) Effects of synaptic blockers on EPSCs in ON αRGCs. Layouts and analyses are the same as in A–C. (H) Ratios of EPSC amplitudes in the presence of blockers to those under control conditions in ON αRGCs (STR: 0.94 ± 0.08, n = 4 cells from three mice; P = 0.49, DNQX + d-AP5: 0.04 ± 0.01, n = 3 cells from three mice; P = 2.42 × 10−4, MFA: 0.05 ± 0.02, n = 4 cells from four mice; P = 2.22 × 10−5). Data are presented as the mean ± SEM. A paired t test was used for statistical analysis. n.s., not significant; **P < 0.01; ***P < 0.001. STR: strychnine.