Characterization of inflammatory monocyte population enriched in Irf3 ^R278Q/R278Q mice. (A) Network plot of the enriched GO terms in monocyte #1. (B) Top ranking ligand–receptor pairs in the NicheNet analysis of communication between monocyte #1 and neurons. (C) Top ranking ligand–receptor pairs in the NicheNet analysis of communication between monocyte #1 and astrocytes. (D) Dot plot showing enriched GO terms at the level of ligands and target cell functions from the NicheNet analysis of the communication between monocyte #1 and oligodendrocytes. (E) Top ranking ligand–receptor pairs in the NicheNet analysis of communication between monocyte #1 and endothelial cells. (F) Dot plot showing enriched GO terms at the level of ligands and target cell functions from the NicheNet analysis of the communication between monocyte #1 and pericytes. The hypergeometric distribution was employed to calculate P values for GO enrichment analysis. The FDR correction was subsequently applied to correct for multiple testing. Adjusted P values are shown using a color range from red (lowest) to blue (highest). P values below 0.05 were considered significant, *P < 0.05, **P < 0.01, and ***P < 0.001. FDR, false discovery rate.