Relative frequency of first manifestation and clinical manifestations in patients with CGD from Latin America during the follow-up time. (A and B) (A) First clinical manifestation (n = 223) and (B) clinical manifestation during life (n = 238). PNM, PNM and other lung infections; hepatosplenomegaly, hepatosplenomegaly, splenomegaly, and hepatomegaly, including liver abscess).