TAK1 inhibitor triggers caspase-8–dependent apoptosis induced by autocrine TNF-TNFR1 signaling in BMDMs. (A and B) Graphs depicting quantification of cell death in BMDMs from mice of the indicated genotypes treated with TAK1 inhibitor (TAK1i, 0.25 µM). Graphs show the mean ± SEM of at least two independent experiments. (C) Immunoblots of BMDMs from mice of the indicated genotypes either untreated (UT) or treated with TAK1i (0.25 µM) for 4 h. (D) Graph depicting quantification of cell death in BMDMs from mice of the indicated genotypes treated with a combination of TNF (T, 20 ng/ml) and the indicated amounts of CHX. Graphs show the mean ± SEM of four independent experiments. Source data are available for this figure: SourceData FS2.
Figure S2.

TAK1 inhibitor triggers caspase-8–dependent apoptosis induced by autocrine TNF-TNFR1 signaling in BMDMs. (A and B) Graphs depicting quantification of cell death in BMDMs from mice of the indicated genotypes treated with TAK1 inhibitor (TAK1i, 0.25 µM). Graphs show the mean ± SEM of at least two independent experiments. (C) Immunoblots of BMDMs from mice of the indicated genotypes either untreated (UT) or treated with TAK1i (0.25 µM) for 4 h. (D) Graph depicting quantification of cell death in BMDMs from mice of the indicated genotypes treated with a combination of TNF (T, 20 ng/ml) and the indicated amounts of CHX. Graphs show the mean ± SEM of four independent experiments. Source data are available for this figure: SourceData FS2.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal