Schematic representation of our working model. LRRK2 is recruited to ruptured lysosomes (likely via RAB12 and CASM), where it phosphorylates and recruits RAB substrates. pRABs recruit their effectors JIP4 and RILPL1. JIP4, through a yet unknown kinesin, elongates the LYTL tubules, whereas RILPL1, via dynein/dynactin, favors tubule retraction.