CDR3 mapping distinguishes the effector functions of Mtb-specific TCR clonotypes. (A and B) (A) UMAP plot with split view (based on cells from LTBI vs. non-LTBI participants) with mapping of TCRs from listed GLIPH2 groups (motifs) established as Mtb antigen–specific, and (B) stacked bar plot showing numbers of αβTCRs from each GLIPH2 group (color) per cluster. (C and D) (C) UMAP plots mapping αβTCRs from GLIPH2 groups estimated to be Mtb-specific, and (D) stacked bar plots showing numbers of TCRs per cluster. (E and F) (E) UMAP plots mapping TCRs from listed GLIPH2 groups responsive to MTB300 and/or lysate stimulation, but not infected macrophages, and (F) stacked bar plots showing numbers of TCRs per cluster. (G and H) (G) UMAP plots mapping annotated viral antigen–specific TCRs (in IEDB) from listed GLIPH2 groups, and (H) stacked bar plots showing numbers of TCRs per cluster. (I and J) (I) Total copy numbers (left axis) and percentage (right axis) of cells per cluster mapping TCRs ([clone count/total cells per cluster] × 100) from established or estimated Mtb-specific GLIPH2 groups that recognized infected macrophages and (J) for annotated viral antigen–specific TCRs.