TCRs with inconsistent CDR3α chains map to clusters with nonspecific CD4 ⁺ T cell responses. Related to Fig. 8. (A and B) (A) UMAP plot with split view (based on the participant’s LTBI status) with mapping of estimated Mtb-specific TCRs from listed GLIPH2 groups containing inconsistent CDR3α homology in response to Mtb-infected macrophages, and (B) stacked bar plots showing their numbers per cluster. (C and D) (C) UMAP plots with mapping of TCRs annotated as viral antigen–specific but with inconsistent CDR3α homology from listed GLIPH2 groups and (D) stacked bar plots showing their numbers per cluster. (E and F) (E) Total copy numbers (left axis) and percentage (right axis) ([clone count/total cells per cluster] × 100) of cells per cluster mapping TCRs linked to a response to infected macrophages from listed GLIPH2 groups containing inconsistent CDR3α homology from known or estimated Mtb-specific GLIPH2 groups, and (F) for annotated viral antigen–specific TCRs. (G and H) (G) Overlaid line graph and (H) correlation plot of percent T cells per cluster that mapped TCRs from all 37 GLIPH2 groups estimated to be Mtb-specific (blue) and viral antigen–specific (red).