Distribution of GLIPH2 groups linked to viral or vaccine control responses. Related to Figs. 3 and 4. (A) Bar graph of GLIPH2 groups (x axis) from ≥1 Cleveland participant estimated to be viral or vaccine antigen–specific. (B) Venn diagrams of numbers of HLA-II alleles shared (or not) between Cleveland and South African participants and percentage of Cleveland HLA alleles expressed by South African participants. (C) Bar graph of GLIPH2 groups (x axis) from ≥3 participants from the combined list of Cleveland and South African TCRs estimated to be viral or vaccine antigen–specific, based on IEDB annotation (red), non-LTBI participants (gray), or control peptide stimulations (stripes), rank-ordered by the sum of the highest TCR copy number (y axis) per condition. (D) Bar graph of mean circulating frequency of Cleveland participants’ TCRβ clonotypes (symbols) as constituents of each GLIPH2 group from the combined list of TCRs after cross-referencing unstimulated PBMCs from Cleveland participants.