Hallmark protective cytokines in lung leukocytes of C57BL/6 and C3HeB/FeJ mice. (a and c) Chord plots showing the CellChat predicted relative interaction contributions of TNF-α and IFN-γ signaling to total interaction activity in each group. Outer circle and arrow colors indicate the predicted sending population, and the inner circle colors indicate the predicted receiving populations. Arrow thickness indicates the overall signaling contribution. (b and d) Dot plots showing expression of the indicated genes in scRNA-seq data. Circle sizes represent the abundance of cells expressing the gene, as a percentage of cells within the cluster. Circle color is proportional to the mean expression of the gene within all cells in the cluster. (e) Violin plot showing expression of Ifng within all cells in the T cell CD4 Ifng cluster at 20 days after infection, with a dot at the mean. Data shown are from a single scRNA-seq experiment, and plots show combined data from cells from N = 3 mice per group.