Model of PI(3)P-mediated regulation of endocytic recycling upon cLTP. Increased PI(3)P synthesis upon cLTP promotes endocytic recycling through the SNX17 and SNX27 pathways and is necessary for the cLTP-dependent structural changes in dendritic spines. Glycine-mediated cLTP (1) activates the CaMKII pathway (2) and promotes the recruitment of the lipid kinase VPS34 to endosomes, leading to an increase in PI(3)P-positive endosomes (3). This rise in PI(3)P levels facilitates the recruitment of the SNX17–Retriever and SNX27–Retromer pathways to dendritic spines (4), leading to increased recycling of cell surface proteins (5). SNX17 and SNX27 mediate the recycling of distinct sets of cell surface proteins, including β1-integrin and the AMPA receptor subunit GluA1, respectively, that are necessary for the cLTP response (6). Created with https://BioRender.com.