Molecular modeling of ADA2 variants G47A, G47R, G47V, G47W, R169Q, E328K, H424N, and Y453C. (A) Comparative plots of the different mutations, which display the variability of B-factor values along the protein backbone compared with the wild target. Blue backbones represent lower fluctuations compared with the wild target; red backbones represent higher fluctuations. (B) Zoom-in of residue R169 in the wild target protein. R169 is shown in magenta. Polar and aromatic interactions are shown as dashed lines. (C) Zoom-in of residue E328 in the wild target protein. E328 is shown in magenta. Polar interactions are shown as dashed lines. (D) Zoom-in of residue Y453 in the wild target protein. Y453 is shown in magenta. Polar interactions are shown as dashed lines.
Figure 6.

Molecular modeling of ADA2 variants G47A, G47R, G47V, G47W, R169Q, E328K, H424N, and Y453C. (A) Comparative plots of the different mutations, which display the variability of B-factor values along the protein backbone compared with the wild target. Blue backbones represent lower fluctuations compared with the wild target; red backbones represent higher fluctuations. (B) Zoom-in of residue R169 in the wild target protein. R169 is shown in magenta. Polar and aromatic interactions are shown as dashed lines. (C) Zoom-in of residue E328 in the wild target protein. E328 is shown in magenta. Polar interactions are shown as dashed lines. (D) Zoom-in of residue Y453 in the wild target protein. Y453 is shown in magenta. Polar interactions are shown as dashed lines.

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