The rhesus DH3-15*01 combines residue features that are advantageous for V2 apex epitope recognition. (a and b) Features of the Indian rhesus macaque and human DH-coding sequence repertoire partitioned by the D gene family. Each dot represents a germline D gene expressed in one of the three forward reading frames with a value corresponding to the total number of residues (length), the number of Tyr, Trp, and Phe residues (aromatic), and the number of Glu and Asp residues (anionic). Boxes extend to the respective D gene family mean value, and whiskers show the standard deviation. Sequences were excluded if stop codons were found in the middle of the coding sequence in any particular reading frame. In panel a, the rhesus DH3-15*01 gene expressed in reading frame two is marked with a red symbol, and rhesus D genes with length and aromatic features equal to DH3-15*01 in reading frame two are marked with green and orange symbols, respectively. In panel b, D genes utilized by HCDR3-dominated human V2 apex lineages are marked according to the legend, and the rhesus DH3-15*01 gene expressed in reading frame two is included as a reference to facilitate comparison.