Figure 1. STIM1 and STIM2 gate IP 3 Rs... | Rockefeller University Press

STIM1 and STIM2 gate IP3Rs opening. The model depicts the pattern of the Ca2+ signal observed in the presence and absence of the STIM isoforms during controlled increase in IP3. A limited and local release of IP3 evokes Ca2+ puffs that never globalize (left panel). Deletion of either STIM1 or STIM2 partially reduced ER Ca2+ level, and the same IP3 stimulus causes the Ca2+ puffs to globalize into a diffuse Ca2+ signal (middle panel). Surprisingly, in the absence of both STIM1 and STIM2, the IP3-mediated Ca2+ puffs never globalize (right panel). In breast cancer cells, Ca2+ puffs stimulate cell migration and invasion, while diffuse Ca2+ signals restrict cell migration and tumorigenesis.

Figure 1.

STIM1 and STIM2 gate IP ₃ Rs opening. The model depicts the pattern of the Ca²⁺ signal observed in the presence and absence of the STIM isoforms during controlled increase in IP₃. A limited and local release of IP₃ evokes Ca²⁺ puffs that never globalize (left panel). Deletion of either STIM1 or STIM2 partially reduced ER Ca²⁺ level, and the same IP₃ stimulus causes the Ca²⁺ puffs to globalize into a diffuse Ca²⁺ signal (middle panel). Surprisingly, in the absence of both STIM1 and STIM2, the IP₃-mediated Ca²⁺ puffs never globalize (right panel). In breast cancer cells, Ca²⁺ puffs stimulate cell migration and invasion, while diffuse Ca²⁺ signals restrict cell migration and tumorigenesis.

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