Molecular characterization of primary DLBCL cases. DLBCL cases are ordered according to categorical assignment to BCR with or without autonomous signaling and secondarily by COO classification. Cases are annotated for their expressed isotype, for MYC, BCL2, and BCL6 translocations as detected by targeted sequencing, and for activating mutations in genes relevant for BCR signaling and NF-κB activation including PIM1 detected by WES. The predicted protein sequence alterations are indicated. Only mutations annotated as “deleterious” by SIFT, “possibly” or “probably” damaging by PolyPhen, or “likely pathogenic” or “pathogenic” by Clinical Significance are shown. The probability of assignment to a molecular cluster is indicated per case. Assignment to consensus clusters was determined by probabilistic calculation. Assignment to LymphGen clusters was performed through the LymphGen data portal.