Survival probabilities of main IUIS categories of IEI/PID and the living status at last news with confidence intervals. Inverse cumulative incidence curves and confidence intervals as described and referenced above. Start = age at diagnosis, stop = age at last news, and event = living status (0 = censored, 1 = deceased first, 2 = curative therapy first). There were 21,206 patients censored; 1,960 patients who deceased first; and 2,901 patients who had a curative therapy first (not showing deaths after curative therapy); roman numbers refer to the IUIS categories for IEI/PID as listed in Fig. 2 B. Numbers at risk present patients in the ESID-R from their age at diagnosis onward until definitive/curative treatment or death.