Major treatment modalities of patients with IEI/PID as recorded in the ESID-R. Relative proportions of major treatments such as IGRT (data on route, interval, and dose were recorded but are not shown), allogeneic HSCT (AlloSCT), autologous GT, and splenectomy. Only a proportion of centers recorded data on immune-modifying treatment (not shown), and the ESID-R does not capture data on antimicrobial therapy. “Unknown/not listed” and IGRT refer to the latest follow-up time point.