Distribution of charged residues and hydrophobicity of the predicted membrane- and cytoplasmic-facing surfaces of H. sapiens, S. rosetta, and S. purpuratus caveolin complexes. (A–F) Space-filling models of the caveolin complexes rotated 90°, showing (A–C) the charge of the amino acids or (D–F) hydrophobicity values. Note that side views in A–C are shown with the surface of the complex, whereas a cut through the center of the complex is shown in D–F.