Summary of the structural features of caveolins suggested by computational modeling predictions. Phylogenetic tree shown on the left-hand side of the table is based on Fig. S1 A. N-VR, N terminus variable region; PM, pin motif; Hook, hook structure; SM, signature motif; CSD, caveolin scaffolding domain; Spoke, spoke region; C-β, C-terminal β-strand; C-VR, C terminus variable region; Pack spirally, whether the protein sequence is predicted to be assembled into a disk-shaped oligomer; CR, charged residues on the hydrophobic (bottom) side of complexes (“+” represents a positive charge, “−” represents a negative charge, and uppercase English letters represent the corresponding amino acid residue abbreviations). Structural features were summarized mainly based on AF2.2 predicted 11-mers unless otherwise noted in the upper right corner of particular features. ●, structural feature was predicted to be present; $◑$⁠, structural feature was predicted to be partially present; ○, structural feature was not predicted to be present. NA, not applicable (corresponding sequences were either missing or shifted due to sequence missing). *, A0A1X7VPY7 was not predicted by AF2.2 to form any homologous disk-like or ring-like complexes. However, it was predicted to form a hybrid complex structure with A0A1X7VRV8. The structural features listed for A0A1X7VPY7 are summarized from the model of the hybrid complex consisting of A0A1X7VPY7 (1 copy) and A0A1X7VRV8 (10 copies).