Conserved structural features of metazoan and choanoflagellate caveolins highlighted by computational modeling predictions. AF2.2 models for 11-mer caveolins from representative species of Choanoflagellatea and 14 different metazoan phyla/superphyla. Models in top three rows are in ribbon mode and colored by pLDDT confidence values. Models in bottom three rows are in surface mode and colored by lipophilicity values. To better demonstrate the distribution pattern of hydrophobicity in surface mode, we applied transparency to the N terminus of F2U793, A0A1X7UHP5, A0A7M7R2L2, Q18879, and the residues near the C terminus of A0A267DC90.