Molecular profile of vascular cells after SCI. (A) UMAP representation of clusters from all vascular cells combining all time points. (B) Expression pattern of annotated marker genes used to identify each vascular cluster. The last row of UMAPs shows the expression of molecular markers used differentiate between arterial, venous, and capillary endothelial cells as previously defined (Vanlandewijck et al., 2018). Endothelial cells on the top row refer to all subtypes except tip cells, which are represented separately. (C) Heatmap of the top DEGs for each vascular subtype. Color of tile indicates z-scored expression and inset stars indicate statistically significant greater expression compared with all other cells combined (adjusted P value < 10−10; Wilcoxon rank-sum with Bonferroni correction). A, arterial; C, capillary; V, venous.