Mutation V618G selectively disrupts functional NMDAR–BK coupling. (A and B) Representative whole-cell current traces recorded from cells expressing NMDAR combinations GluN1-GluN2BWT, GluN1-GluN2BV15M, and GluN1-GluN2BV618G alone; and (B) co-expressed with BK after 1-s application of 1 mM glutamate (purple square over the traces) evoked at the indicated membrane potentials. (C) Normalized I-V (top) and charge-voltage (Q-V, middle) relationships for NMDAR inward currents. All plots refer to NMDAR/BK currents. Bottom: Qoutward/Qinward relationships versus voltage. Data points in all graphs represent mean ± SEM; n = 5–7.
Figure 2.

Mutation V618G selectively disrupts functional NMDAR–BK coupling. (A and B) Representative whole-cell current traces recorded from cells expressing NMDAR combinations GluN1-GluN2BWT, GluN1-GluN2BV15M, and GluN1-GluN2BV618G alone; and (B) co-expressed with BK after 1-s application of 1 mM glutamate (purple square over the traces) evoked at the indicated membrane potentials. (C) Normalized I-V (top) and charge-voltage (Q-V, middle) relationships for NMDAR inward currents. All plots refer to NMDAR/BK currents. Bottom: Qoutward/Qinward relationships versus voltage. Data points in all graphs represent mean ± SEM; n = 5–7.

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