Site location of disease-linked GRIN2B mutations within the structure of NMDAR (PDB: 7SAA ) ( Chou et al., 2022 ). The GluN1 subunit is colored in gray, and the GluN2B subunit is depicted in purple. All subunits contain three main regions, indicated on the left side of the figure: N-terminal domain (NTD), ligand-binding domain (LBD), and transmembrane domain (TMD). The position of residue V15 is not shown since it is in the signal peptide (see also [Hu et al., 2016]). Mutation V618G is in the pore lining region within the TMD. The inset shows amplified images of specific regions containing disease-linked mutations. For reference, two other mutations targeting the LBD (R540H) or the TMD (N615I) are shown. The protein structure was visualized using UCSF ChimeraX (Meng et al., 2023).