CoMtb shapes early immune cell responses. (A–C) Related to Fig. 3: CoMtb accelerates T cell and MDC activation, blunts neutrophil responses. (A) GSEA analysis comparing CoMtb to primary Mtb infection across time points, corresponding to Fig. 3 A. (B)Ifng expression at d10 in our scRNAseq dataset, across all major cell types. (C) Pulmonary bacterial burdens corresponding to Fig. 3 F. FDR determined by the R fgsea package. Single-group comparisons by unpaired t test. (D and E) Related to Fig. 4. CoMtb shapes early tuberculous lesion cellularity and organization. (D) 1–2 color images from identical ROIs are shown in T cell panels in Fig. 4 A depicting density of CD4 T cells surrounding PPD in the lesions of primary and CoMtb mice. Scale bar: 50 μm. (E) Flow cytometry determination of the proportion and MFI of MHCII in MDCs, data from Fig. 2 E. Single-group comparisons by unpaired t test. **P < 0.01, ***P < 0.001, ****P < 0.0001, and ns, P ≧ 0.05. FDR, false discovery rate.