Grouping by recorded α-subunit, β1 subunit co-expression, and cell type does not create distinct clusters and only explains a small part of the observed between-experiment variability. The number after each category indicates the corresponding number of means. Within-study between-experiment variability is observed in the two largest studies but is much smaller than in the full data set. (A) Grouping by α-subunit: from largest to smallest subgroup, we show the a* (R1027Q) α-subunit, b (Q1077del), not reported, a (Q1077), and b* (T559A; Q1077del). (B) Grouping by β1 co-expression. (C) Grouping by cell type (HEK versus CHO cells), but note the very different group sizes. (D) The largest subgroup versus all other results. (E and F) Within-study variability in the works by Kapplinger et al. (2015) and F, Tan et al. (2005). The blue line in E and F is the linear regression line to the full data set shown in Fig. 3.
Figure 4.

Grouping by recorded α-subunit, β1 subunit co-expression, and cell type does not create distinct clusters and only explains a small part of the observed between-experiment variability. The number after each category indicates the corresponding number of means. Within-study between-experiment variability is observed in the two largest studies but is much smaller than in the full data set. (A) Grouping by α-subunit: from largest to smallest subgroup, we show the a* (R1027Q) α-subunit, b (Q1077del), not reported, a (Q1077), and b* (T559A; Q1077del). (B) Grouping by β1 co-expression. (C) Grouping by cell type (HEK versus CHO cells), but note the very different group sizes. (D) The largest subgroup versus all other results. (E and F) Within-study variability in the works by Kapplinger et al. (2015) and F, Tan et al. (2005). The blue line in E and F is the linear regression line to the full data set shown in Fig. 3.

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