Tri-phasic LV-pressure dose response to DN and OM. (A and B) LV pressure response to a continuous infusion of either (A) DN at 6 mg/kg/min or (B) OM at 1 mg/kg/min parameterized by the maximum LV pressure (P_max), minimum LV pressure (P_min), the maximum rate of LV pressure change (dP/dt_max), and minimum rate of LV pressure change (dP/dt_min). The x axis represents the cumulative infused dose. The three different phases of the LV pressure response (P1, P2, and P3) are marked with dashed lines. (C) Doses at which the pressure response transitions from phase 1 to phase 2 (P1 → P2) and phase 2 to phase 3 (P2 → P3) for DN and OM. N = 4 mice/group.