Schematic representation of primary cilium–dependent FGFR2 signalling. (A) FGFR2 is transported to the plasma membrane from the Golgi through intracellular vesicles, which get activated only after translocation to the primary cilium. (B) After FGF10 stimulation, FGFR2 transduces the signal through MEK and ERK1/2 kinases and activates the downstream genes to control tissue growth, differentiation, and homeostasis. (C) FGFR2 expression in the primary cilium is maintained by IFT144 and Bbs1 molecules before targeting it to the LAMP1 vesicles.