Type 2 diabetic phenotype of adipocyte-specific Trx2-KO mice. (A) Growth curves of male WT and Trx2^ADKO mice (n = 8). (B) EchoMRI analysis of fat and lean mass of 14-wk-old male WT and Trx2^ADKO mice (n = 8). (C and D) Oxygen consumption corrected for TBW (C) and oxygen consumption corrected for TBW (D). EE, energy expenditure. (E and F) Blood glucose levels in random fed WT and Trx2^ADKO male (E) and female mice (F). Both male and female mice exhibited similar phenotypes in blood glucose levels (n = 8 for each group). (G and H) GTT (G) and ITT (H) results of 6-wk-old male WT and Trx2^ADKO mice (n = 8). AUC (120 min) was calculated. Quantitative data represent the mean ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001 compared with WT controls. Significance was analyzed by two-tailed Student’s t test.