IL-17A–driven transcriptional reprogramming of cecal fibroblasts sustains type 3/Th17 niche. (A) Representative bright-field microscopy image of fibroblasts cultured from the cecum. Scale bar = 100 µm. (B) Heatmap of the top 50 differentially expressed genes in cecal fibroblasts following direct exposure to IL-17A at 20 and 200 ng/ml, compared with control conditions. (C) GO functional enrichment analysis of the top 50 differentially expressed genes. (D) KEGG functional enrichment analysis revealing key signaling pathways activated by IL-17. Data are presented as adjusted P values for pathway enrichment.