Group-specific TF core regulatory circuitries are co-opted in NSCs. (a) Similarity of group 1 and group 2 GSC samples along with NSC samples (n = 7) by consensus clustering of the 10% most variable regions by H3K27ac signal (n = 16,817). (b) Median H3K27ac signal (rpm/bp) at SEs in group 1–like NSCs and group 1 GSCs (top). Median H3K27ac signal (rpm/bp) at SEs (bottom) in group 2–like NSCs and group 2 GSCs. (c) Schematic showing (1) the identification of NSCs similar to group 1 and group 2 GSCs by their H3K27ac landscape and (2) the identification of conserved and differential TFs of group 1 and group 2 GSCs compared with NSCs. (d) Classifying the NSCs into group 1–like GSCs (n = 4) and group 2–like GSCs (n = 3) based on their average similarity with the group 1 and group 2 GSC samples (left) and the similarity of NSCs within themselves (right). Similarity measure was obtained by consensus clustering of the 10% most variable regions by H3K27ac signal (n = 16,817). (e) Median H3K27ac signal (rpm/bp) at SEs of group 1–specific TFs (top) in group 1–like NSCs and group 1 GSCs (top). Median H3K27ac signal (rpm/bp) at SEs of group 2–specific TFs (bottom) in group 2–like NSCs and group 2 GSCs. (f) Row-normalized gene expression levels (log₂FPKM) of the group-specific TFs for group 1 and group 2 GSCs along with NSCs.