ISG expression in splenic cell populations. (A) OR representing enrichment of ISGs among downregulated (FDR < 0.05, LFC less than −1) genes. Activated NK cells show the highest downregulation of ISGs among all splenic cell populations. P values (Fisher’s exact test) are shown, and populations with significant downregulation of ISGs (P < 0.05) are shown in blue. P values are adjusted using Holm–Bonferroni method. ns (not significant) for P ≥ 0.05. (B) Average ISG expression in cell populations with the most significant ISG downregulation, based on A. Upregulated and downregulated genes are shown in red and blue, respectively; ISGs are labeled. Data are obtained from one experiment with four Aire-deficient (KO) and three control (HE) animals per group.
Figure S4.

ISG expression in splenic cell populations. (A) OR representing enrichment of ISGs among downregulated (FDR < 0.05, LFC less than −1) genes. Activated NK cells show the highest downregulation of ISGs among all splenic cell populations. P values (Fisher’s exact test) are shown, and populations with significant downregulation of ISGs (P < 0.05) are shown in blue. P values are adjusted using Holm–Bonferroni method. ns (not significant) for P ≥ 0.05. (B) Average ISG expression in cell populations with the most significant ISG downregulation, based on A. Upregulated and downregulated genes are shown in red and blue, respectively; ISGs are labeled. Data are obtained from one experiment with four Aire-deficient (KO) and three control (HE) animals per group.

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