Figure S12.
![Effect of open and closed RyR2 block on the time course of [Ca2+] in the cytoplasm and LSR and Ca2+fluxes.(A–D) The control conditions and figure format are the same as Fig. S11. (E and F) Green lines show a threefold reduction in the opening rate (closed channel block), and red lines show a threefold increase in the closing rate (open channel block). Refer to the image caption for details.](https://cdn.rupress.org/rup/content_public/journal/jgp/157/3/10.1085_jgp.202413543/2/jgp_202413543_figs12.png?Expires=1783135432&Signature=tFp9o17m0AsGMC9pghFRxKr7bxY7FhmPTrbg-R-p6G6rdzsL-y7dOcEfXE5XeOgrAymnj2pSgVnK2sqYZvZYJLsF8oYtNt74HvcQWNiCzyMX5vYtacrxfFOcZkyxENkEmIvnTvaamvEXm-vw9r6Y0cgsDpU09L1R36X375H6Mj-jfDHKf6IfM~Pgp0~fmYnL1cnJSjWblDgn73CwHi81B8GaqtAlcAsTYeQ8uko~-fC2VZyEww~QNdAMPD90q9FUpqVufxReGK3xvy-azFEHySUASH3cMl-Z8~EFOoANvghOGTvplILAd~jL~o-r4bSCWQxD8o0uGMvmy-dCFDuMDA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Effect of open and closed RyR2 block on the time course of [Ca 2+ ] in the cytoplasm and LSR and Ca 2+ fluxes. (A–D) The control conditions and figure format are the same as Fig. S11. (E and F) Green lines show a threefold reduction in the opening rate (closed channel block), and red lines show a threefold increase in the closing rate (open channel block).