Figure 5.
![Ca2+ time courses during a Ca2+ wave. (A–D) Time course of Ca2+ in the cytoplasm and LSR in model cells with RyR2 from sheep/human (A and B) and rat (C and D). (A and B) Ca2+ waves near the longitudinal axis (x = 1 μm and y = 1 μm, z = 25 μm [near the midpoint of the longitudinal axis]) for simulations with uniform RyR2 cluster sizes (black) and exponentially distributed cluster sizes (green). Ca2+ waves near the cell exterior (x = 7 μm and y = 1 μm, z = 25 μm) from uniform clusters (red). External [Ca2+] = 0.3 μM as indicated by the dashed line in A. (C and D) Ca2+ waves in rat using uniform clusters near the longitudinal axis (black) and cell exterior (red). Refer to the image caption for details.](https://cdn.rupress.org/rup/content_public/journal/jgp/157/3/10.1085_jgp.202413543/2/jgp_202413543_fig5.png?Expires=1783135372&Signature=L6SUIci899NEDTr7jxYBK0anmrLGY72irkLygR9-fMXrjGZEKIRVlEz2k~9RWfqZu5zyWbsHc0Y2JNREBbLBiE12KVv~hBf0dL1fqC1drLDqvFiIdu88Yn9Lyg8Tz4frbc3jonfEbtGxMpTmNb2s-Iyk0fYog2Exl51BZ~x7g~hNytnG7lMEVFEuvYVIosFwkqNuhotu~6LVitAzgKpmMMr99a0pXeWVCLYMLp2Mwe-s2fJx5GnTqSeN57Ry6~uPEbFTjf2oZs0~fioSY1DHmYfdNn5gKjfJqIyfxUsi~CY7HtXQ6rGOKfugWKSKDxEXGAFNYwgltasve7E5hvcmTw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Ca2+ time courses during a Ca2+ wave. (A–D) Time course of Ca2+ in the cytoplasm and LSR in model cells with RyR2 from sheep/human (A and B) and rat (C and D). (A and B) Ca2+ waves near the longitudinal axis (x = 1 μm and y = 1 μm, z = 25 μm [near the midpoint of the longitudinal axis]) for simulations with uniform RyR2 cluster sizes (black) and exponentially distributed cluster sizes (green). Ca2+ waves near the cell exterior (x = 7 μm and y = 1 μm, z = 25 μm) from uniform clusters (red). External [Ca2+] = 0.3 μM as indicated by the dashed line in A. (C and D) Ca2+ waves in rat using uniform clusters near the longitudinal axis (black) and cell exterior (red).