Figure 3. Effect of LSR [Ca 2 ] on Ca 2... | Rockefeller University Press

Figure 3.

Effect of LSR [Ca2+] on Ca2+release from a cluster of 25 RyRs in a dyad cleft. (A) Time course of [Ca2+] in the dyad (third concentric ring) at various LSR [Ca2+] showing termination of Ca2+ release within 40 ms for LSR [Ca2+] up to 0.9 mM and continuous Ca2+ release at higher LSR [Ca2+]. (B) Dependence of the threshold LSR [Ca2+] for onset of continuous Ca2+ release on the bath (cytoplasmic) [Ca2+]. (C) Cytoplasmic [Ca2+] at dyad #3 due to embers occurring at dyads #1 and #2. The labels indicate their initial transients. (D) Cumulative probability of an ember triggering Ca2+ release at a nearest neighbor dyad (0.25 μm away). Refer to the image caption for details.

Effect of LSR [Ca ²⁺ ] on Ca ²⁺ release from a cluster of 25 RyRs in a dyad cleft. (A) Time course of [Ca²⁺] in the dyad (third concentric ring) at various LSR [Ca²⁺] showing termination of Ca²⁺ release within 40 ms for LSR [Ca²⁺] up to 0.9 mM and continuous Ca²⁺ release at higher LSR [Ca²⁺]. (B) Dependence of the threshold LSR [Ca²⁺] for onset of continuous Ca²⁺ release on the bath (cytoplasmic) [Ca²⁺]. (C) Cytoplasmic [Ca²⁺] at dyad #3 due to embers occurring at dyads #1 and #2. The labels indicate their initial transients. (D) Cumulative probability of an ember triggering Ca²⁺ release at a nearest neighbor dyad (0.25 μm away).